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Moritz Rossner. Genetic models of psychiatric risk genes, behavioural biology of mouse models, stem cell-based human cell systems, transcriptome analyses, genetic interference analyses. Most psychiatric disorders have complex genetic and environmental causes. Genetic and environmental factors interact with each other in ways that are largely unknown and that, in unfavourable combinations, lead to disorders of brain function. Recent findings indicate a high level of genetic relatedness between psychiatric disorders such as schizophrenia, depression and bipolar disorders that previously have only been defined clinically.